Tobramycin Inhalation Powder Dose AssessmentAdult
Useful Management Information
The TOBI podhaler containing tobramycin powder for inhalation is a bacterial antibiotic used to treat Pseudomonas aeruginosa infections in patients with cystic fibrosis.
Indications:
Before using TOBI podhaler, the patient must be assessed for bronchial hyperresponsiveness.
Contraindications:
- Do not perform in patients who are hypersensitive to tobramycin, any of the inactive ingredients (1,2-distearoyl-sn-glycero-3-phosphocholine [DSPC], calcium chloride, and sulphuric acid for pH adjustment) or to any other aminoglycoside antibacterial.
- Acute myocardial infarction within 1 week.
- Systemic hypotension or severe hypertension.
- Significant atrial/ventricular arrhythmia.
- Non-compensated heart failure.
- Uncontrolled pulmonary hypertension.
- Acute cor pulmonale.
- Clinically unstable pulmonary embolism.
- History of syncope related to forced expiration/cough.
- Cerebral aneurysm.
- Brain surgery within 4 weeks.
- Recent concussion with continuing symptoms.
- Eye surgery within 1 week.
- Sinus surgery or middle ear surgery or infection within 1 week.
- Presence of pneumothorax.
- Thoracic surgery within 4 weeks.
- Abdominal surgery within 4 weeks.
- Late term pregnancy.
- Active or suspected transmissible respiratory or systemic infection including tuberculosis.
- Physical conditions predisposing to transmission of infections.
The safety and effectiveness of the TOBI podhaler has not been established in patients:
- With an FEV1 <25% and >80% predicted.
- With auditory or vestibular dysfunction.
- With renal dysfunction.
- With neuromuscular dysfunction.
- With hepatic impairment.
- Patients under 6 years of age and over 65 years of age.
- Who have had organ transplantation.
- Who are pregnant or breastfeeding.
- Who are colonized with Burkholderia cepacia.
Minimum Referral Criteria
Category Category 1 ((appointment within 30 calendar days)) |
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Category Category 2 ((appointment within 90 calendar days)) |
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Category Category 3 ((appointment within 365 calendar days)) |
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If your patient does not meet the minimum referral criteria
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Essential Referral Information
- Reason for referral - what is the clinical question to be answered by performing the test?
- Current respiratory medications.
- Infectious status.
If a specific test result is unable to be obtained due to access, financial, religious, cultural or consent reasons a Clinical Override may be requested. This reason must be clearly articulated in the body of the referral.
Additional Referral Information
- No additional referral information
Send Referrals To
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Internal Referrals
Lung Function Lab (E-Blueslips)
Fax
Post
Lung Function Lab
Gold Coast University Hospital
1 Hospital Boulevard
Southport QLD 4215
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If you would like to send a named referral, please address it to the specialist listed above, who will allocate a suitably qualified specialist to see the patient. Alternatively, you can view a full list of our specialists.